Ora Weisz, Ph.D.

  • Professor of Medicine, Cell Biology, Clinical and Translational Science
  • Division of Renal-Electrolyte

Education & Training

  • Ph.D. in Biochemistry, Cell, and Molecular Biology from Johns Hopkins School of Medicine, Baltimore, M , 1990
  • B.S. in Molecular Biophysics & Biochem from Yale University, New Haven, CT, 1984
  • B.S. in History from Yale University, New Haven, CT, 1984

Research Interest Summary

Regulation of apical membrane traffic in health and disease

Research Categories

Research Interests

Research in the Weisz lab focuses broadly on understanding how membrane traffic in proximal tubule cells responds to physiologic cues to maintain kidney function. Her team is developing kinetic and imaging approaches to define the apical endocytic pathway in these cells and to elucidate the mechanisms by which the proximal tubule efficiently recovers filtered proteins and small molecules. Additionally, she has been generating new in vitro and ex vivo systems, including disease models, to try to unravel how proximal tubule cells in the kidney alter endocytic and ion transport capacity in response to changes in tubular flow. Her studies have direct implications for the understanding and treatment of genetic and other disorders that result in tubular proteinuria and eventually lead to kidney failure, including Lowe syndrome, Dent disease, and sickle cell disease. Dr. Weisz has a strong interest in career development, and in addition to their research, graduate students in the laboratory are encouraged to take advantage of management and leadership training programs to facilitate their advancement in a broad range of future careers.

Representative Publications

Youker RT, Bruns JR, Costa SA, Rbaibi Y, Lanni F, Kashlan OB, Teng H, and Weisz OA. (2013) Multiple motifs regulate apical sorting of p75 via a mechanism that involves dimerization and higher-order oligomerization. Mol Biol Cell. 24:1996-2007.

Raghavan V, Rbaibi R, Pastor-Soler N, Carattino MD, and Weisz OA (2014) Shear stress dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci USA.111:8506-8511. PMCID: 4060694.

Pereira EM, Labilloy A, Eshbach ML, Roy A, Subramanya AR, Monte S, Labilloy G, and Weisz OA (2016) Characterization and phosphoproteomic analysis of a human immortalized podocyte model of Fabry disease generated using CRISPR/Cas9 technology. Am J Physiol- Renal Physiol. 311:F1015-F1024. PMID: 27681560.

Eshbach ML, Kaur A, Rbaibi Y, Tejero J, and Weisz OA (2017) Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. Am J Physiol- Cell Physiol. 312:C733-C740.

Eshbach ML, Sethi R, Avula R, Lamb J, Hollingshead DJ, Finegold DN, Locker J, Chandran UR, and Weisz OA (2017) The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line. Am J Physiol- Renal Physiol. 313:F585-F595.

Long KR, Shipman KE, Rbaibi Y, Menshikova E, Ritov VB, Eshbach ML, Jiang Y, Jackson EK, Baty CJ, and Weisz OA (2017) Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell. 28:2508-2517.

Ren Q, Gliozzi ML, Rittenhouse NL, Edmunds LR, Rbaibi Y, Locker JD, Poholek AC, Jurczak MJ, Baty CJ, and Weisz OA (2019) Shear stress and oxygen availability drive differential changes in OK proximal tubule cell metabolism and endocytosis. Traffic. 20:448-459.

Gliozzi ML, Rbaibi Y, Long KR, Vitturi DA, and Weisz OA (2019) Hemoglobin alters vitamin carrier uptake and vitamin D metabolism in proximal tubule cells: implications for sickle cell disease. Am J Physiol- Cell Physiol. 317:C993-C1000. 

Gliozzi ML, Espiritu E, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, and Weisz OA (2020) Effects of proximal tubule shortening on protein excretion in a Lowe Syndrome model. J Am Soc Nephrol. 31:67-83. 

Long KR, Rbaibi Y, Gliozzi ML, and Weisz OA (2020) Differential kidney proximal tubule cell responses to protein overload by albumin and its ligands. Am J Physiol- Renal Physiol. 318:F851–F859.

Ren Q, Weyer K, Rbaibi Y, Long KR, Tan RJ, Nielsen R, Christensen EI, Baty CJ, Kashlan OB, and Weisz OA (2020) Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin. Am J Physiol- Renal Physiol. 318:F1284-1294.

Full List of Publications