Matthew Steinhauser, M.D.

  • Associate Professor
  • Aging Institute

Education & Training

  • 1998: BS, Microbiology, University of Michigan, Ann Arbor
  • 2002: MD, University of Michigan Medical School, Ann Arbor

Research Interest Summary

We study the intersection between aging, adipose tissue dysfunction, and cardiometabolic diseases.

Research Categories

Research Interests

My laboratory is broadly interested in how metabolism is altered by and contributes to disease. Within this context, the lab is focused in three inter-related areas: (1) We study how systemic metabolic function is modulated by local cellular and molecular derangements in adipose tissue arising during development, aging, or in contexts of energy imbalance. (2) We have developed novel stable isotope- based methods to study metabolism. This includes a new quantitative imaging platform called multi- isotope imaging mass spectrometry (MIMS). We have established MIMS as a powerful tool for interrogation of cell turnover and metabolism, in situ, at sub-organelle resolution with studies in model organisms and more recently with first-in-human studies. (3) We are undertaking a major effort to define the molecular and metabolic responses to physiological stressors of relevance to aging biology that drive resiliency.

Representative Publications

Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012; 481(7382):516-9.

Kim SM, Lun M, Wang M, Senyo S, Guillermier C, Patwari P, Steinhauser ML. Loss of white adipose hyperplastic potential is associated with enhanced susceptibility to insulin resistance. Cell Metabolism. 2014; 20: 1049-58.

Fazeli PK, Lun M, Kim SM, Bredella MA, Wright S, Zhang Y, Lee H, Catana C, Klibanski A, Patwari P, Steinhauser ML.  FGF21 and the late adaptive response to starvation in humans. J Clin Invest. 2015; 125: 4601-11.

Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH Jr, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML*, Fox CS. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nature Genetics. 2017. 49: 125-30. *co-corresponding author

Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML. Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity. JCI Insight. 2017. 2: e90349.

Zhang Y, Federation AJ, Kim S, O’Keefe J, Lun M, Xiang D, Brown JD, Steinhauser ML. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. J Clin Invest. 2018. 128(11): 4898-4911.

Guillermier C, Doherty SP, Whitney AG, Babaev VR, Linton MF, Steinhauser ML*, Brown JD. Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis. JCI Insight. 2019. 4(11): e1285528. *co-senior author
Narendra DP, Guillermier C, Gyngard F, Huang X, Ward ME, Steinhauser ML. Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover. J Cell Biol. 2020. 219(1): e201901097.

Fazeli PK, Zhang Y, O’Keefe J, Pesaresi T, Lun M, Lawney B, Steinhauser ML. Prolonged fasting drives a program of metabolic inflammation in human adipose tissue. Molecular Metabolism. 2020. DOI: 10.1016/j.molmet.2020.101082.

Monji A, Zhang Y, Kumar GVN, Guillermier C, Kim S, Olenchock B, Steinhauser ML. A cycle of inflammatory adipocyte death and regeneration in murine adipose tissue. Diabetes. 2022. doi: 10.2337/db20-1306. Online ahead of print

Full List of Publications