D. Lansing Taylor, Ph.D.

  • Director, University of Pittsburgh Drug Discovery Institute
  • Department of Computational and Systems Biology

Education & Training

  • Ph.D. in Cell Biology from State University of New York at Albany
  • B.S. in Zoology, University of Maryland

Research Interest Summary

The application of quantitative systems pharmacology to drug discovery, including the use of human, 3D, microfluidic models of human disease.

Research Categories

Research Interests

My academic interests link large-scale cell, tissue and human, biomimetic, tissue-engineered in vitro disease model profiling with computational and systems biology to optimize drug discovery and diagnostics. I am also developing computational tools to identify and quantify heterogeneity. As the Director of the Drug Institute, I am focusing our efforts in Quantitative Systems Pharmacology in order to change the paradigm in drug discovery, development and diagnostics.

Representative Publications

Giuliano KA, Premkumar D, Strock C, Johnston PA, Taylor DL. (2009) Cellular systems biology applied to cellular models of disease. Comb Chem High Throughput Screen. 12(9):838-48. PMID: 19531002.

Nederlof M, Watanabe S, Burnip B, Taylor DL, Critchley-Thorne R. (2011) High-throughput profiling of tissue and tissue model microarrays: combined transmitted light and 3-color fluorescence digital pathology. J Pathol Inform. 2:50. PMID: 22200032. PMCID: PMC3237061.

Taylor DL. (2012) A new vision for drug discovery and development. Eur Pharm Rev. 17(6):20-24.

Bhushan A, Bale SS, McCarty WJ , Hegde M, Jindal R, Golberg I, Usta OB, Yarmush ML, Senutovitch N, Vernetti L, Gough A, Bakan A , Shun TY, DeBiasio R, Taylor DL. (2013)Towards a 3D microfluidic liver platform for predicting drug efficacy and toxicity in humans. J Stem Cell Res & Therapy, 4 (Suppl): S16.

Bale SS, Vernetti L, Senutovitch N, Jindal R, Hedge M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, Golberg I, DeBiasio R, Usta OB, Taylor DL, Yarmush ML. (2014). In Vitro platforms for evaluating liver toxicity. J Exp Biol Med (Maywood). Sep: 239(9):1180-91. PMID: 24764241. PMCID: PMC4156546.

Gough A, Chen N, Shun TY, Lezon T, Boltz RC. Reese C, Wagner J, Grandis J, Lee A, Stern A, Schurdak M, Taylor DL. (2014) Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. PLoS ONE. 9(7) e102678. PMCID: PMC4103836.

Gough AG, Lezon T, Faeder JR, Chennubhotla C, Murphy RF, Critchley-Thorne R, Taylor DL. (2014) High content analysis and cellular and tissue systems biology: a bridge between cancer cell biology and tissue-based diagnostics. In/The Molecular Basis of Cancer, 4th Ed. (Mendelsohn J, Howley PM, Israel MA, Gray JW, Thompson CB) Elsevier, NY.

Cobanoglu, MC, Oltvai ZN, Taylor, DL, Bahar, I. BalestraWeb: Efficient online evaluation of drug-target interactions. Bioinformatics Oct 8, 2014. 1-3.

Vernetti L, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. (2015) A human liver microphysiology platform for investigating physiology, drug safety and disease models. J Exp Biol Med (in press).

Senutovitch N, Vernetti, L, Boltz, R, DeBiasio, R, Gough, A, Taylor, DL. (2015) Fluorescent Protein Biosensors Applied to Microphysiological Systems. J Exp Biol Med (in press).